Podcast EP #106 | Benefits of Progesterone in Women and Men: Why the Uterus Was Never the Point
Progesterone got filed under women’s health. Then, inside women’s health, it got filed again, under the uterus. That second filing is the one that does the damage. If you’re prescribing progesterone for endometrial protection, good.
Podcast EP #105 | DHT Causes Hair Loss… Except When It Doesn’t
DHT causes hair loss, but the mechanism is more complex than most providers were taught. Dihydrotestosterone (DHT) can miniaturize hair follicles in genetically sensitive individuals, but it can also promote hair growth under different conditions.
Podcast EP #104 | Cortisol and Hormones: What the Physiology Actually Shows
You have a patient who should be better by now. Her estradiol is where you want it. Her progesterone is dosed. She still wakes at three in the morning, still carries weight around the middle,
Podcast EP#103 | Are Seed Oils Bad for You? A Provider’s Guide
You have met this patient. She is doing everything right on paper. Her hormones are dialed in, she is finally sleeping, she has cleaned up her exposures. And she still cannot lose the weight. Her
Podcast EP #102 | Early Puberty and Xenoestrogens: What It Means for Your HRT Patients
A century ago, the average girl got her first period around 16 or 17. Today it’s closer to 12, and that’s just the average. Something changed, and it changed far too fast to be genetic.
Podcast EP #101 | The Estrobolome: Why Optimal Estrogen Labs Still Miss Estrogen Dominance
You have seen this patient. Her estradiol reads optimal. You have checked it two or three times. And she is still bloated, still constipated, still dealing with breast tenderness, heavy cycles, and the irritability that
Podcast Ep #99 | How to Market a Medical Practice
Here is what I see over and over again when providers ask how to market a medical practice. They get their logo designed, pick their brand colors, name the clinic, and then hand the whole
Podcast EP #98 | How to Build a Cash-Pay HRT Clinic: Mastery First, Marketing Last
I want to talk about the stuff nobody told me when I was building my own clinic. Most of what providers get told about how to build a cash-pay HRT clinic is backwards. I learned
Podcast EP 97 | Birth Control Is Not Treatment: Alternatives to Birth Control for PCOS, Acne, and PMS
EDITORIAL NOTE: In May 2026, The Lancet renamed PCOS to PMOS, polyendocrine metabolic ovarian syndrome. The new name reflects the metabolic and endocrine reality this episode describes. Full adoption in international guidelines is projected for
POD EP #96 | Hormones and Depression: Why SSRIs Are Not the Full Answer
The patient has been on an antidepressant for eight months. Still fatigued. Still not sleeping. Still sitting across from you with the same flat look she had at her first visit. Normal panel, two dose
Compounded HRT Medications: Why the Anti-Compounding Argument Contradicts Itself
There is a vocal group of providers in this space who will not touch compounded HRT medications. Their argument sounds like rigor. Nico posted about it recently, and the response told him it landed somewhere
Starting Your Own Healthcare Practice as a Nurse Practitioner
Starting an independent healthcare practice is both exciting and intimidating. Many providers dream of practicing medicine on their own terms, but the path to independence requires careful planning, persistence, and a strong commitment to patient
Peptide Safety in Hormone Therapy: Lessons from Medical History
Peptides are becoming an increasingly common topic in hormone therapy and clinical medicine. As new therapies emerge, questions about safety naturally follow, especially when long-term human data is limited. In this episode, Nico Misleh addresses
Patient Retention Strategies for Healthcare Practices: How to Keep Patients Long-Term
Patient retention is one of the most important but often overlooked aspects of running a successful healthcare practice. While many providers focus heavily on marketing and patient acquisition, the long-term sustainability of a practice often
Progesterone and Brain Health: Debunking the Cognitive Decline Myth
Progesterone is one of the most misunderstood hormones in medicine. It plays a critical role in hormone replacement therapy, and misinformation about its safety keeps circulating anyway. Lately I keep hearing that oral progesterone might
Serotonin and Bone Loss in Post-Menopausal Women
When a post-menopausal patient comes in asking about bone health, estrogen is usually the first conversation. And for good reason: estrogen decline is one of the most well-established drivers of bone loss after menopause. But
Health Insurance for Independent Medical Providers
Introduction For many medical professionals, the idea of starting an independent practice is both exciting and intimidating. Autonomy, entrepreneurship, and clinical freedom are powerful motivators. However, one major concern consistently holds providers back from making
POD Ep #85 | Thyroid Combination Therapy and Hormone Replacement
Introduction Thyroid health is one of the most underexamined layers in hormone replacement therapy. Most clinicians were trained to approach hypothyroidism in a straightforward way. Diagnose. Prescribe levothyroxine. Normalize TSH. Reassure. But if you practice