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A GLP-1 course for providers, taught as physiology.

A mechanism-first course on semaglutide, tirzepatide, and retatrutide, for the clinicians who prescribe them. Built on the incretin system, not on a weight number. Taught by Nico Misleh, MSN, FNP-C, in the HRT University system.

7 modules
6 hours of video
Jointly Accredited

Special Launch Price $499

Price after September 30th $559

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THE problem

Understand how every GLP-1 drug actually works.

GLP-1 receptor agonists are now among the most prescribed drugs in the country, and the prescribing has outpaced the education. Almost any clinician can tell you they cut appetite. Far fewer can explain how semaglutide, tirzepatide, and retatrutide actually differ, or what that difference means for the patient in the room.
What each agent does to mitochondrial function and energy expenditure.
Why the half-lives make these weekly drugs, and why daily microdosing adds nothing.
How a patient’s hormonal environment changes the response.
What happens metabolically when a patient stops, and how to plan for it from day one.
Primary care starts semaglutide after a fifteen-minute visit. Weight-loss clinics stack tirzepatide on top of untreated thyroid disease and hypogonadism. Patients cycle on and off with no plan. GLP-1 Optimization closes that gap. It teaches the mechanism, so you prescribe from physiology instead of from a chart.

HOW WE TEACH IT

Most GLP-1 training stops at the prescription.

Search for a GLP-1 course and you’ll find weight-loss certifications, dosing protocols to memorize, and revenue playbooks. Useful for billing, thin on biology. Here’s the thing though: these aren’t weight-loss drugs. GLP-1 is a systemic hormone, not a gut hormone, and its receptor sits across the brain, heart, pancreas, liver, gut, kidneys, and lungs. We teach the mechanism, so you can think across all three agents and build the plan around the patient instead of following a chart.

HOW IT'S USUALLY TAUGHT

Frames these as weight-loss drugs for a BMI number.
One dosing protocol to follow for everyone.
Built around cash-pay revenue, “practice in a box.”
Treats semaglutide and tirzepatide as interchangeable.
Skips retatrutide and the mechanism behind the class.
Stops at the prescription. No plan for muscle or for stopping.

HOW WE TEACH IT

Teaches the incretin mechanism so you individualize dosing.
Built around patient physiology and the hormonal foundation.
Differentiates all three agents by receptor, outcome, and evidence.
Covers semaglutide, tirzepatide, and retatrutide by generation.

Protects lean mass and plans deprescribing from day one.

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What's Included in the GLP-1 Course

A Workbook built against the lectures

  • Every reference and tool is clickable in the online workbook
  • Print it and work alongside the videos, for individual use only
  • Full APA reference list, so you can read the primary literature yourself

An AI companion for course questions

  • Ask questions about any lecture and get answers from the course material
  • Work back through a mechanism while you are still in the module
  • Runs in the app alongside the videos

The confidence to prescribe from physiology

  • Tell the agents apart by receptor, not by marketing
  • Titrate to tolerance, set a maintenance dose, protect lean mass
  • Plan for discontinuation before the first injection
Inside the Lecture Files

Watch a few minutes first.

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THE SEVEN MODULES

Seven modules, built mechanism-first.

It moves from the physiology of the incretin system, through each compound, into clinical management, tolerability, and the myths patients bring in.
01

Introduction

The incretin system, receptor distribution across the body, why endogenous GLP-1 erodes, the pharmacology of modified compounds, and the clinical hierarchy.
02

Semaglutide

The GLP-1 standard. Mechanism, ADME, titration from 0.25 to 2.4 mg, the STEP and SELECT evidence, safety, and the best candidate.
03

Tirzepatide

What GIP adds as a second receptor, the mitochondrial dual pathway, dosing, the body-composition advantage, and DEXA monitoring.
04

Retatrutide & comparison

What glucagon adds, thermogenesis and energy expenditure, Phase 2 dosing and safety, and the three compounds head to head.
05

Clinical management

Expectations and benchmarks, the timeline of loss, too slow and too fast, protecting muscle, discontinuation, maintenance, and microdosing.
06

GI management

The GLP-1 standard. Mechanism, ADME, titration from 0.25 to 2.4 mg, the STEP and SELECT evidence, safety, and the best candidate.
07

Myths & summary

The misconceptions retired against the evidence, the three compounds at a glance, the clinical mindset, and the full APA reference list.
ACCREDITATION

Built for credit, across professions.

HRT University courses run on a Joint Accreditation framework for interprofessional continuing education, so one course can carry credit for physicians, nurse practitioners, physician assistants, pharmacists, and more. CE credit for GLP-1 Optimization is in development. We’ll post the exact credit type and hours here once the runtime is set. Join the waitlist to be notified.

Nurse Practitioners
Physician Assistants
MDs
DOs
Naturopathic Doctors
Pharmacists
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WHO IT'S FOR

Built for the clinicians who prescribe.

Licensed prescribers who want to understand the mechanism instead of following a package schedule.

The clinician

You can prescribe, and you want to choose the right agent for each patient, then manage therapy through tolerability, body composition, and discontinuation. Not stop at the first script.

The patient is a physiology, not a BMI

BMI is a regulatory threshold, not a biological cut-off. The mechanism applies to the metabolically impaired but non-obese, the hormonally optimized with residual dysfunction, and indications like lean PCOS, metabolic syndrome, and NASH.
group 69
Meet your instructor

Nico Misleh

MSN
FNP-C

“Optimize the hormonal foundation before you initiate. Match the compound to the mechanism and the patient’s biology, not to marketing. Monitor lean mass as seriously as total weight. And plan for discontinuation from day one.”

Nico teaches hormone and metabolic medicine to licensed providers through HRT University. GLP-1 Optimization sits inside the HRTU sequence as the metabolic medicine course that builds on the hormone-optimization foundation.

More About Nico
FAQ

Questions, answered.

Licensed prescribers: NPs, PAs, MDs, DOs, NDs, and pharmacists who can prescribe and manage GLP-1 therapy within their scope. A clinician course, not a patient course.

HRT University is a jointly accredited continuing education provider, partnered with Pinnacle Conference, LLC, to deliver CE credit across multiple healthcare professions. Every accredited activity meets the standards set by ACCME, ACPE, and ANCC for educational quality, clinical independence, and evidence-based content.

The GLP1 Course is accredited with 6CE (6RX) Hours. 

It’s mechanism-first. You learn the incretin physiology and how each receptor changes the picture, so you can pick the right agent and individualize dosing instead of following a schedule.