A GLP-1 course for providers, taught as physiology.
A mechanism-first GLP- 1 course for the clinicians who prescribe them. Built on the incretin system, not on a weight number. Taught by Nico Misleh, MSN, FNP-C, in the HRT University system.
Course Price $559
3 year access
THE problem
Understand how every GLP-1 drug actually works.
GLP-1 receptor agonists are now among the most prescribed drugs in the country, and the prescribing has outpaced the education. Almost any clinician can tell you they cut appetite. Far fewer can explain how all the GLP-1s actually differ, or what that difference means for the patient in the room.
What each agent does to mitochondrial function and energy expenditure.
How a patient’s hormonal environment changes the response.
What happens metabolically when a patient stops, and how to plan for it from day one.
Primary care starts GLP-1s after a fifteen-minute visit. Weight-loss clinics stack tirzepatide on top of untreated thyroid disease and hypogonadism. Patients cycle on and off with no plan. GLP-1 Optimization closes that gap. It teaches the mechanism, so you prescribe from physiology instead of from a chart.
HOW WE TEACH IT
Most GLP-1 training stops at the prescription.
Search for a GLP-1 course and you’ll find weight-loss certifications, dosing protocols to memorize, and revenue playbooks. Useful for billing, thin on biology. These aren’t weight-loss drugs. GLP-1 is a systemic hormone, not a gut hormone, and its receptor sits across the brain, heart, pancreas, liver, gut, kidneys, and lungs. We teach the mechanism, so you can think across all three agents and build the plan around the patient instead of following a chart.
HOW IT'S USUALLY TAUGHT
Treats the single and dual agonists as interchangeable.
Skips the triple agonist and the mechanism behind the class.
HOW WE TEACH IT
Covers the single, dual, and triple agonists by generation.
Protects lean mass and plans deprescribing from day one.
What's Included in the GLP-1 Course
A Workbook built against the lectures
- Every reference and tool is clickable in the online workbook
- Print it and work alongside the videos, for individual use only
- Full APA reference list, so you can read the primary literature yourself
An AI companion for course questions
- Ask questions about any lecture and get answers from the course material
- Work back through a mechanism while you are still in the module
- Runs in the app alongside the videos
The confidence to prescribe from physiology
- Tell the agents apart by receptor, not by marketing
- Titrate to tolerance, set a maintenance dose, protect lean mass
- Plan for discontinuation before the first injection
THE SEVEN MODULES
Seven modules, built mechanism-first.
Introduction
The single-receptor agonist
Mechanism, ADME, titration from 0.25 to 2.4 mg, the STEP and SELECT evidence, safety, and the best candidate.
Adding GIP
Adding glucagon, and the three compared
What glucagon adds, thermogenesis and energy expenditure, Phase 2 dosing and safety, and the three compounds head to head. The triple agonist holds no FDA approval and cannot be prescribed or compounded. It is taught as pharmacology.
Clinical management
GI management
Why nausea happens and why it usually passes, what to counsel before the first injection, the fixes for nausea, constipation and bloating, thyroid insufficiency and SIBO as hidden causes, and holding a dose instead of stopping.
Myths & summary
ACCREDITATION
Built for credit, across professions.
HRT University courses run on Joint Accreditation for interprofessional continuing education, so one course can carry credit for physicians, nurse practitioners, physician assistants, pharmacists, and more. GLP-1 Optimization carries 6 CE contact hours, all of them pharmacotherapy (6RX).
WHO IT'S FOR
Built for the clinicians who prescribe.
The clinician
The patient is a physiology, not a BMI
BMI is a regulatory threshold, not a biological cut-off. The mechanism applies to the metabolically impaired but non-obese, the hormonally optimized with residual dysfunction, and indications like lean PCOS, metabolic syndrome, and MASH.
Meet your instructor
Nico Misleh
“Optimize the hormonal foundation before you initiate. Match the compound to the mechanism and the patient’s biology, not to marketing. Monitor lean mass as seriously as total weight. And plan for discontinuation from day one.”
Nico teaches hormone and metabolic medicine to licensed providers through HRT University. GLP-1 Optimization sits inside the HRTU sequence as the metabolic medicine course that builds on the hormone-optimization foundation.
FAQ
Questions, answered.
Who is it for?
Licensed prescribers: NPs, PAs, MDs, DOs, NDs, and pharmacists who can prescribe and manage GLP-1 therapy within their scope. A clinician course, not a patient course.
Does it offer CE credit?
HRT University is a jointly accredited continuing education provider, partnered with Pinnacle Conference, LLC, to deliver CE credit across multiple healthcare professions. Every accredited activity meets the standards set by ACCME, ACPE, and ANCC for educational quality, clinical independence, and evidence-based content.
GLP-1 Optimization is accredited for 6 CE hours (6RX).
How is this different from a protocol or dosing chart?
Which compounds are covered?
All three, by receptor: the single-receptor agonist, the GIP/GLP-1 dual agonist, and the investigational triple agonist. The triple agonist holds no FDA approval and cannot be prescribed or compounded. It is taught as pharmacology so you can answer the question when a patient asks. Every compound is named and taught by name inside the course.